12 research outputs found
Water-soluble bis(1,10-phenanthroline) Octanedioate Cu2+ and Mn2+ Complexes with Unprecedented Nano and Picomolar in Vitro Cytotoxicity: Promising Leads for Chemotherapeutic Drug Development
Dinuclear CuII and MnII bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O2 dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity
Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development
Dinuclear Cu2+ and Mn2+ bis-phenanthroline octanedioate compounds exhibit rapid, unprecedented
nano and picomolar in vitro cytotoxicity against human-derived colorectal cancer lines (HT29, SW480
and SW620) and are less cytotoxic toward non-cancerous normal human keratinocyte cells (HaCaT).
Both complexes displayed greater in vivo drug tolerance compared to cisplatin when examined using the
insect Galleria mellonella. The compounds are potent generators of intracellular reactive oxygen species
within HT29 cells, display avid DNA binding and induce O2-dependent cleavage of supercoiled pUC18
DNA. The Cu2+ complex was found to display self-cleaving nuclease activity and a mechanism of
deoxyribose C–H bond activation is proposed, based on interactions with the superoxide anion and
hydrogen peroxide along with DNA cleavage observations under anaerobic conditions and with an
excess of the metal chelator EDTA
Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development
Dinuclear Cu2+ and Mn2+ bis-phenanthroline octanedioate compounds exhibit rapid, unprecedented
nano and picomolar in vitro cytotoxicity against human-derived colorectal cancer lines (HT29, SW480
and SW620) and are less cytotoxic toward non-cancerous normal human keratinocyte cells (HaCaT).
Both complexes displayed greater in vivo drug tolerance compared to cisplatin when examined using the
insect Galleria mellonella. The compounds are potent generators of intracellular reactive oxygen species
within HT29 cells, display avid DNA binding and induce O2-dependent cleavage of supercoiled pUC18
DNA. The Cu2+ complex was found to display self-cleaving nuclease activity and a mechanism of
deoxyribose C–H bond activation is proposed, based on interactions with the superoxide anion and
hydrogen peroxide along with DNA cleavage observations under anaerobic conditions and with an
excess of the metal chelator EDTA
Water-soluble CuII and MnII bis-phenanthroline octanedioate complexes with unprecedented nano and picomolar in vitro cytotoxicity as promising leads for chemotherapeutic drug development
Dinuclear CuII and MnII bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O2 dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity